Right-back Stephen Kelly looks set to make his Reading debut in the Barclays Premier League game at Newcastle.
Midfielder Hope Akpan could also start his first match for the Royals following his move from Crawley.
Striker Jason Roberts (hip) and goalkeeper Alex McCarthy (shoulder) are out but midfielder Mikele Leigertwood is available after recovering from an unspecified knock.
Reading (from): Federici, Ugwu, Taylor, Gunter, Kelly, Cummings, Pearce, Morrison, Mariappa, Shorey, Harte, McAnuff, Carrico, Akpan, Tabb, Karacan, Kebe, McCleary, Robson-Kanu, Leigertwood, Le Fondre, Hunt, Pogrebnyak.
Newcastle manager Alan Pardew could welcome back Steven Taylor.
The defender has returned to training after recovering from a hamstring injury suffered in November and could feature, while striker Shola Ameobi is available after he missed last weekend's goalless draw with Norwich through suspension.
Fabricio Coloccini looks set to continue in the Newcastle defence despite continuing rumours linking him with a move back to Argentina but Hatem Ben Arfa remains sidelined.
Newcastle (from): Krul, Elliot, Tavernier, Perch, Williamson, Coloccini, Debuchy, Santon, Gutierrez, Anita, Cabaye, Cisse, Bigirimana, Obertan, Sammy Ameobi, Amalfitano, Marveaux, Abeid, Ranger, Ferguson, Shola Ameobi, Taylor.