Midfielder Ki Sung-yueng misses out with a hamstring problem, while his preferred replacement Kemy Agustien is struggling with a toe injury.
Leon Britton also has a knock while winger Pablo Hernandez is nursing an ankle injury, although defender Chico Flores is set to return from a dead leg.
Should Agustien be unavailable, Laudrup may opt to move top scorer Michu back into midfield and hand Danny Graham or Itay Shechter a start up front.
Provisional squad: Flores, Tate, Williams, Britton, Michu, Graham, Hernandez, Dyer, Cornell, Routledge, Monk, Shechter, Moore, De Guzman, Tiendalli, Rangel, Tremmel, Agustien, Gower, Richards, Davies.