The Italian left-back has been missing since the 4-0 loss against Tottenham Hotspur earlier in the campaign with a knee problem.
And his chances of a comeback were also reduced after he went down with a bout of tonsillitis which ruled him out of Saturday’s win over Crystal Palace and the midweek clash with Everton.
Santon will be ready to battle Paul Dummett and Massadio Haidara for the left-back slot.
Which asks the question ... what the hell has happened to Massadio Haidara these days?
He has only made two Premier League starts since his transfer from AS Nancy 15 months ago.
He suffered that horror tackle from Wigan midfielder Callum McManaman that kept him out of the side through injury, but he has been fit to play for some six months now.
Some suggest the tackle has done more than just physical damage, and his attitude towards playing in the Premier League has changed.
Another half-hearted player is the last thing we need right now.
We already have a couple of those, as we saw on Tuesday evening.