It will be Newcastle's 39th match of the season (due to involvement in the InterToto Cup), more than any other Premiership side. Glenn Roeder faces one of his former clubs.
The Magpies are unbeaten in six Premiership games against West Ham. The Tyneside club are also aiming for their second 'double' of the season having won home and away against Spurs.
West Ham seek a first away win of the season. They're three points behind fourth bottom Wigan.
The Upton Park club have not scored in nine successive away games in the Premiership.
Referee Uriah Rennie is long remembered for sending off Alan Shearer in the first game of the 1999/2000 season against Aston Villa when he didn't even touch the defender.
PREMIERSHIP YEARS: MAGS v HAMMERS
2006/2007 Sun 17 Sep West Ham Utd. 0 - 2 Newcastle Utd. Premiership
2005/2006 Sat 17 Dec West Ham Utd. 2 - 4 Newcastle Utd. Premiership
Sat 20 Aug Newcastle Utd. 0 - 0 West Ham Utd. Premiership
2002/2003 Sat 11 Jan West Ham Utd. 2 - 2 Newcastle Utd. Premiership
Mon 19 Aug Newcastle Utd. 4 - 0 West Ham Utd. Premiership
2001/2002 Sat 27 Apr Newcastle Utd. 3 - 1 West Ham Utd. Premiership
Sun 23 Sep West Ham Utd. 3 - 0 Newcastle Utd. Premiership
2000/2001 Mon 16 Apr Newcastle Utd. 2 - 1 West Ham Utd. Premiership
Sat 28 Oct West Ham Utd. 1 - 0 Newcastle Utd. Premiership
1999/2000 Wed 12 Apr West Ham Utd. 2 - 1 Newcastle Utd. Premiership
Mon 03 Jan Newcastle Utd. 2 - 2 West Ham Utd. Premiership
1998/1999 Sat 20 Mar West Ham Utd. 2 - 0 Newcastle Utd. Premiership
Sat 31 Oct Newcastle Utd. 0 - 3 West Ham Utd. Premiership
1997/1998 Sat 07 Feb Newcastle Utd. 0 - 1 West Ham Utd. Premiership
Sat 20 Sep West Ham Utd. 0 - 1 Newcastle Utd. Premiership
1996/1997 Tue 06 May West Ham Utd. 0 - 0 Newcastle Utd. Premiership
Sat 16 Nov Newcastle Utd. 1 - 1 West Ham Utd. Premiership
1995/1996 Mon 18 Mar Newcastle Utd. 3 - 0 West Ham Utd. Premiership
Wed 21 Feb West Ham Utd. 2 - 0 Newcastle Utd. Premiership
1994/1995 Wed 08 Mar Newcastle Utd. 2 - 0 West Ham Utd. Premiership
Wed 31 Aug West Ham Utd. 1 - 3 Newcastle Utd. Premiership
1993/1994 Sat 19 Mar West Ham Utd. 2 - 4 Newcastle Utd. Premiership
Sat 25 Sep Newcastle Utd. 2 - 0 West Ham Utd. Premiership