Argentina won 1-0 in Uruguay on Wednesday to book their place at next summer's World Cup, while Honduras are also heading to South Africa.
Diego Maradona's Argentina progressed as substitute Mario Bolatti hit a late winner to end Uruguay's hopes of snatching the final automatic qualification berth in the South American zone.
Bolatti fired home with six minutes remaining after the home defence failed to deal with Juan Sebastian Veron's effort from a free-kick.
Uruguay ended the night with 10 men after Martin Caceres picked up a second yellow card in the build up to Argentina's winner.
Maradona has come in for fierce criticism for his disjointed handling of Argentina's qualification campaign, which as seen him call up over 70 players, but the 1-0 victory in Montevideo should silence his critics - until next summer at least.
Uruguay, meanwhile, now need to prevail in a play-off against Costa Rica if they are to join Argentina in the finals.