Tomer Hemed's strike denied Newcastle the chance to move fourth in the Premier League as Brighton prevailed 1-0 at the Amex Stadium.
Hemed's second Premier League goal sealed the Seagulls' triumph and manager Chris Hughton's first win over former club Newcastle at the seventh time of asking.
Brighton moved 13th in the table with their second win of the campaign, hitting back after losing at Bournemouth in first the Premier League then the Carabao Cup this past week.
Israel forward Hemed added to his goal in the 3-1 home win over West Brom to tie up three more priceless points for Brighton, finishing smartly from Dale Stephens' tee-up.
Newcastle were the only side to do the double over Brighton in the Sky Bet Championship last season, but the Seagulls exacted some revenge in edging out the in-form visitors.
On Saturday ... Raheem Sterling scored twice as Sky Bet’s odds-on title favourites Manchester City maintained their unbeaten start to the Premier League season with a comfortable 5-0 victory over struggling Crystal Palace.
Leroy Sane put City in front just before the break after latching on to David Silva's lofted pass, lobbing the ball over Scott Dann and poking through the legs of Wayne Hennessey.
The Germany winger then turned provider as Sterling easily side-footed his cross from the left under the diving Hennessey from eight yards in the 51st minute.
Sterling added his second eight minutes later from Sergio Aguero's low cross before the Argentina forward netted the fourth and Fabian Delph rounded off the rout late on.
Palace, who have yet to pick up a point or score in the league this season, remain bottom of the table, four points adrift of safety, after six games.
Manchester United had boss Jose Mourinho sent to the stands late on, but remain hot on the heels of their table-topping neighbours after seeing off Southampton 1-0 at St Mary's.
Romelu Lukaku lashed in his sixth Premier League goal of the season from close range after seeing his initial header well saved by Fraser Forster in the 20th minute.
Mourinho's side are also unbeaten and are level on 16 points with City, but find themselves sitting in second place courtesy of an inferior goal difference.
Alvaro Morata grabbed a hat-trick as Chelsea extended their unbeaten run in the league to five games with a 4-0 victory at Stoke.
Morata opened the scoring in the second minute by lashing home right-footed from Cesar Azpilicueta's ball over the top before Darren Fletcher gifted Pedro the second on the half-hour mark.
Former Real Madrid striker Morata added his second of the day after 77 minutes and, moments later, he completed his first treble for the Blues.
Philippe Coutinho scored his first goal of the season as Liverpool held on to claim a thrilling 3-2 victory at Leicester in the late game.
Coutinho, the subject of three bids from Barcelona in the summer, fired home a stunning first-half free-kick to add to Mohamed Salah's early opener.
The Foxes hit back through Shinji Okazaki's goal just before the break but the Reds restored their two-goal lead through Jordan Henderson after 68 minutes.
Jamie Vardy grabbed a goal back for Leicester just a minute later and then had the chance to level with a penalty but Simon Mignolet atoned for his foul on the striker by saving his spot-kick.
In the early kick-off, Tottenham survived a late West Ham onslaught to emerge with a 3-2 win.
Harry Kane scored twice in four first-half minutes and Spurs appeared to be cruising when Christian Eriksen added a third.
Javier Hernandez pulled one back before Serge Aurier marked his full Spurs league debut with a needless red card.
Cheikhou Kouyate halved the deficit, but Tottenham held on to extend their unbeaten run to six games in all competitions.
Oumar Niasse continued his Everton renaissance to score twice and complete a 2-1 comeback against Bournemouth at Goodison Park.
Josh King put the Cherries in front after 49 minutes before Niasse - who emerged from an 18-month exile in midweek - scored twice in five minutes late on.
Richarlison scored a last-gasp winner as Watford secured a 2-1 victory over Swansea at the Liberty Stadium.
Watford forward Andre Gray scored his first goal for the club before substitute Tammy Abraham's equaliser but Richarlison had the final word in the 90th minute.
Elsewhere, Burnley were held to a 0-0 draw by Huddersfield at Turf Moor as both sides continued their impressive start to the season.