The likes of Alan Smith, Damien Duff and Charles N'Zogbia will hope to benefit from their absence, although Emre has been allowed to join up with the Turkey squad early ahead of their Euro 2008 finals campaign and James Milner has not sufficiently recovered from the foot injury which has sidelined him for two months.
Keegan decided several weeks ago not to risk Shay Given again this season after groin surgery, while Stephen Carr has been told he can leave the club and Peter Ramage has decided not to stay.
Everton may well be unchanged as Mikel Arteta is recovering back home in Spain following a stomach operation.
They need just one point to be sure of fifth place and their third European qualification in four seasons.
Only a defeat by Newcastle and an Aston Villa win at West Ham on the final day will rob the Toffees of automatic qualification for the UEFA Cup.
Tony Hibbert will continue at right-back, with skipper Phil Neville in the holding midfield role he occupied in last weekend's 1-0 defeat at Arsenal.
Everton (from): Howard, Hibbert, Yobo, Jagielka, Lescott, Baines, Valente, Carsley, Neville, Osman, Fernandes, Pienaar, Johnson, Yakubu, Anichebe, Wessels, Rodwell, Gosling.
Newcastle (from): Harper, Forster, Beye, Enrique, Taylor, Faye, Edgar, Cacapa, Diatta, Butt, N'Zogbia, Duff, Geremi, Owen, Smith, Martins, Carroll.