Bournemouth manager Eddie Howe: "Newcastle have been on a good run. They've changed systems a few times and have been very hard to beat. I expect a tough game.
"We want to find that consistency. I've sensed a desire and attitude within the group to end the season on a high. This is a big game for us."
Newcastle are unbeaten in three league and cup visits to Bournemouth since a 2-1 defeat in the second tier in September 1989.
The Cherries only need a point to match last season's final total of 26 at the Vitality Stadium.
All seven of Bournemouth's home league defeats since losing to Burnley in November 2017 have come against established top-six sides.
Wilson and Ryan Fraser have combined for nine Premier League goals this season - the last pair to do so 10 times in a single top-flight campaign were Arsenal's Nicolas Anelka and Dennis Bergkamp 20 years ago.
Newcastle are winless in six away matches, earning just two points.
The Magpies have lost seven consecutive Premier League away games in March without scoring since a 4-1 victory at Hull City in 2014.
They have only scored 11 goals in 17 Premier League away fixtures since last April.
Six-goal Ayoze Perez is the highest scorer in the division this season yet to score away from home.
Salomon Rondon has been involved in 13 Premier League goals for Newcastle this season (eight goals, five assists) - five more than any other player.
Jonjo Shelvey's next league appearance will be his 100th for Newcastle.