Rafa Benitezmust choose between Aleksandar Mitrovic and Daryl Murphy.
Ayoze Perez and Yoan Gouffran can also play up front.
“Murphy has been doing really well and Mitrovic has been doing well,” said Benitez.
“I am happy with my options. I have Gouffran and Ayoze too.”
Gayle has scored 22 goals this season, putting him two behind Leeds’ Chris Wood, who tops the Championship scoring chart.
“The best thing for Gayle is he recovers quickly,” said Benitez.
“He has an eye on the golden boot.
“Maybe we can help him by keeping Chris Wood quiet. He’s a strong striker who can win in the air and run and finish.”