Keeper Tim Krul, midfielder Yoan Gouffran and striker Papiss Cisse, who came off the bench to score a match-saving double against Hull on Saturday, have all been struck down by a virus and will not travel.
In addition, defender Davide Santon (knee), midfielders Siem de Jong (thigh) and Rolando Aarons (hamstring), and striker Adam Campbell (hernia) are still out.
Marouane Chamakh remains Crystal Palace's biggest doubt for the Selhurst Park clash.
The Morocco striker missed Saturday's 3-2 Premier League win at Everton with hamstring trouble and may not be risked for the midweek cup contest.
Deadline day recruit Zeki Fryers is still waiting for his first start since making the switch from Tottenham.
Crystal Palace (from): Speroni, Hennessey, Mariappa, Kelly, Fryers, Ward, Delaney, Dann, Hangeland, Jedinak, McArthur, Bannan, Ledley, Williams, Bolasie, Thomas, Puncheon, Gayle, Campbell, Johnson, Doyle, Chamakh, Zaha.
Newcastle (from): Krul, Elliot, Janmaat, Dummett, Haidara, Coloccini, Williamson, S. Taylor, Tiote, Anita, Abeid, Gouffran, Sissoko, Colback, Cabella, Obertan, Ameobi, Riviere, Cisse, Perez, Armstrong.