Guthrie was public enemy number one in the eyes of the Hull supporters after the horror tackle which broke Tigers forward Craig Fagan's leg in September.
Fagan, coincidentally, was making his first start since that game and his battle against Guthrie added extra spice to the match.
Despite being booed heavily with every touch, Guthrie made a useful early contribution by playing in Owen, whose cross was headed straight at Matt Duke by Andrew Carroll.
Fagan also got into the action early on but shot well wide.
Fagan brought up a huge cheer after 26 minutes when he fouled Guthrie despite it being in dangerous territory, but Newcastle wasted the free-kick.
Newcastle earned a remarkable reprieve in the 72nd minute as Given clutched a ball Hull were convinced had crossed the line.
Turner rose to head a Dean Marney corner which Duff headed onto the angle of crossbar and post.
Given smothered the bouncing ball as Hull claimed a goal but Foy and his assistant were unmoved.