To make matters even worse for Newcastle, goalkeeper Shay Given could also be ruled out of Monday's Tyne-Tees derby with Middlesbrough - and possibly beyond - due to a suspected broken bone in his thumb.
Souness: "Shay Given may have broken a bone in his thumb as well, so it's not been a good afternoon for us. It looks like it will keep him out of the Middlesbrough game.
"He's had it X-rayed but we've not had the results back yet. There's a great deal of swelling and that can sometimes hide any damage. We can't be too precise just yet."
Newcastle full-back Peter Ramage could also be doubtful for the Boro game, having been replaced by Celestine Babayaro at half-time, shortly after being caught out as Teemu Tainio put Spurs ahead.
Souness: "Ramage was feeling his calf on one leg and his Achilles on the other leg. He had a difficult 45 minutes and that's unfortunately where they got their breakthrough from."