Newcastle fans will never forget that horror tackle on Massadio Haidara that could have ended the player's career.
But the Toon player is back in action, and McManaman saw his career reach a new level as he graced Wembley yesterday.
Roberto Martinez: "It's an incredible moment. At half-time we were all really down as we thought we had played really well in the first half.
"There was a real feeling of maybe we had wasted our opportunity, but this group of players keep on fighting.
"I was thinking about extra-time and how to use the extra man advantage. It was incredible seeing the goal going in.
"Callum McManaman has been through a lot in the last few months. I always said he is one of the biggest diamonds in British football at his very young age. He is a man for the big occasions.
"He hasn't got many starts under his belt but he was typifying what Wigan Athletic is. I couldn't be prouder for him.
"He is not fussed about anything. He is not one of those who wants to wear the best shoes or drive the best cars. He comes in, give him a football and he is a happy man. That's the way he plays.
"The one-to-one situation was a real threat for us all afternoon. It was a very good performance.'
"What an incredible story.
"The chairman broke his leg in 1960 and today, finally, it's finished business for him."
MAN CITY 0 WIGAN 1
Ben Watson's last-minute header gave Wigan the FA Cup for the first time in their history as they provided one of the competition's great upsets by beating Manchester City at Wembley.
Watson turned home Shaun Maloney's corner to flatten 10-man City, who had Pablo Zabaleta sent off near the end.
It was a deserved triumph for the Latics, for whom Callum McManaman was outstanding, and completed a personal dream for chairman Dave Whelan, who broke his leg in the 1960 final.
But for City, it means a trophyless campaign and raises further questions over the future of Roberto Mancini, who it is rumoured will be replaced by current Malaga boss Manuel Pellegrini in the summer.
The pre-match touchline conversation between Mancini and chairman Khaldoon al-Mubarak would have been interesting considering the rumours flying around about the potential recruitment of Pellegrini.
After all, City were aiming to land meaningful silverware for a third successive season for only the second time in their history.
It is true to say City's targets have changed markedly thanks to the money invested by Sheikh Mansour, but, as Roman Abramovich has discovered, and Tony Fernandes has done so painfully this season, money guarantees nothing.
The Blues supporters certainly made their feelings known, chanting Mancini's name at regular intervals and coming out with something pretty unkind about Pellegrini, who has confirmed he will leave Malaga in the summer.
It was not that long though before they were starting to becoming critical of their own team.
For Wigan, boss Roberto Martinez came up with an ingenious way of trying to overcome the massive odds stacked against his team.
In leaving Arouna Kone and McManaman upfield even as City pressed, he forced the Blues to temper their attacking instincts, denying them the width which adds to the obvious danger their flair players pose.
When the half-time whistle blew City could claim most of the best chances.
But in Joel Robles, preferred in goal to Ali Al Habsi, Wigan had a keeper in form.
The Spain Under-21 star turned away an early effort from Yaya Toure and denied Sergio Aguero and Samir Nasri later in the half.
In the middle was the best of the lot as Wigan's notoriously flaky defence parted to let Nasri through, which allowed David Silva to set up Carlos Tevez.
The Argentina star looked certain to score as his effort headed to one corner as Robles plunged towards the other.
Somehow though, the on-loan Atletico Madrid man kept it out with his legs, one of those moments that ends up being etched in final history if Robles were to end up on the winning side.
And Wigan had chances to get their noses in front during that opening period too.
McManaman was a constant threat.
But running onto Kone's pass and then electing to check inside and curl home with his left foot rather than shooting first-time with his right, then embarking on a Ricky Villa-like slalom and driving a shot against Zabaleta, he wasted the best of them.
Not that he could be blamed 18 minutes after half-time when he embarked on a bewitching run into the City box and was only denied by Vincent Kompany's brave block.
City had improved overall, with James Milner introduced to provide an extra boost to the midfield effort.
Emmerson Boyce got a vital touch to Aguero's near-post flick and substitute Jack Rodwell had a long-range effort charged down as Mancini excuted a tactical rejig to counter Martinez's attacking intentions.
It was Wigan who hit the woodwork though, albeit unintentionally as Maloney's intended far post free-kick bounced off the bar with Joe Hart stranded.
And they had an extra man six minutes from the end when Zabaleta chopped down McManaman to collect a second yellow card and follow Kevin Moran and Jose Antonio Reyes into the FA Cup final hall of shame.
It was the signal for another Wigan assault, and by now no-one could deny they deserved something from the game.
Two free-kicks came and went before another McManaman burst forced Gael Clichy to concede a corner.
Maloney swung it to the near post and Watson rose to power it into the corner and carve Wigan's name into history