The first leg of the tie will be at St James’ Park on September 24, with the return at the Mycom Stadium, Breda on October 15.
NAC finished fourth in Eredivisie last season to qualify for the tournament, but were an amazing 28 points behind third placed Feyenoord.
UEFA Cup first round draw
AIK Stockholm v Valencia
Dinamo Bucharest v Shakhtar Donetsk
Maccabi Haifa v CMC Publikum
Torpedo Moscow v CSKA Sofia
Dundee v Perugia
Cementarnica 55 v Lens
Newcastle v NAC Breda
Benfica v La Louviere
Panionios v FC Nordsjaelland
Hearts v Zeljeznicar Sarajevo
Udinese v SV Salzburg
Genclerbirligi v Blackburn
Puchov v Barcelona
Dinamo Zagreb v MTK Hungaria
H. Ramat-Gan v Lefski Sofia
Kaiserslautern v FK Teplice
FK Sartid v Slavia Prague
Villarreal v Trabzonspor
Grasshoppers v Hajduk Split
Hertha Berlin v Groclin Dyskobolia
Liverpool v Olimpija Ljubljana
Valerenga v Graz AK
CSF Zimbru v Aris Salonika FC
Copenhagen v Ferencvaros
Varteks v Debrecen
Hamburg v Dnipro
Bordeaux v Artmedia Petrzalka
Roma v Vardar
Man City v Lokeren
Spartak Moscow v Esbjerg
Wisla Krakow v NEC Uniao
Leiria v Molde
Austria Vienna v Borussia Dortmund
Auxerre v N Xamax
FK Ventspils v Rosenborg
Gaziantepspor v Hapoel Tel-Aviv
Odense BK v Crvena Zvezda
Sporting Lisbon v Malmo FF
FC Utrecht v MSK Zilina
Metalurg Zaporizhzhya v Parma
MyPa v Sochaux
Schalke v Kamen Ingrad
Mallorca v APOEL Nicosia
Southampton v Steaua Bucharest
Feyenoord v FC Karnten
PAOK Salonika v Lyn
Malatyaspor v Basle
Brondby v Zizkov