The 31-year-old defender returned from international duty with Argentina with a groin problem, but having been assessed by the club's medics, he will play no part against the Reds.
Alan Pardew: "We have had an injury to Colo in the international break, so he won't feature this weekend.
"How long he misses, we will have to wait and see, so that was disappointing.
"He has a groin injury, so we will have to see how it repairs itself over the next few days."
Mapou Yanga-Mbiwa has been challenged to fill Coloccini’s boots against Liverpool – and help Newcastle United stop Luis Suarez and Daniel Sturridge.
Yanga-Mbiwa was dropped for the club’s last game, the 2-1 win at Cardiff City.
The defender had paid the price for Newcastle’s defensive problems in the 3-2 defeat at Everton.
Alan Pardew: “Mapou will play. He came out of this team, but he has put in some strong performances for this football club.
“Certainly, it takes time to adjust to the Premier League.
“I remember Coloccini’s first year here. Sometimes it takes some adjusting. What we’ve done is give him some solutions to get the best out of him.
“You are looking for a bit of character in a player. We’ve seen that in him.
“He’s a player with tremendous pace. He has to utilise that. If he can do that, he is going to be a massive asset for us.
“We paid a lot of money for Mapou. We are hoping he can get Premier League football in a short period of time. He is growing as a player, and he will get better.
"Suarez and Sturridge are arguably the strongest strike partnership in the division.
“When you play against these two particular strikers, they give you all sorts of problems.
“They play in front of you. So your line is important, and your units have to be close. So our midfield has got as an important a job as our back four.”
Saturday October 19
12:45 Newcastle United v Liverpool
15:00 Arsenal v Norwich City
15:00 Chelsea v Cardiff City
15:00 Everton v Hull City
15:00 Man Utd v Southampton
15:00 Stoke City v West Brom
15:00 Swansea City v Sunderland
17:30 West Ham United v Manchester City
Sunday October 20
16:00 Aston Villa v Tottenham
Monday October 21
20:00 Crystal Palace v Fulham
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NEWCASTLE UNITED 2013/14
CARDIFF CITY 1 NEWCASTLE 2 (Remy 2)
Krul, Debuchy, Williamson, Coloccini, Santon, Tiote, Cabaye (86' Ben Arfa), Gouffran, Sissoko, Remy (71' Gutierrez), Cisse
Subs: Anita, Yanga-Mbiwa, Elliot, Sammy Ameobi, Dummett
EVERTON 3 NEWCASTLE 2 (Cabaye, Remy)
Krul, Debuchy, Yanga-Mbiwa (46' Williamson), Coloccini, Santon, Tiote, Anita (69' Cisse), Ben Arfa (46' Cabaye), Sissoko, Gouffran, Remy
Subs: Elliot, Obertan, Sammy Ameobi, Dummett
NEWCASTLE 2 HULL CITY 3 (Remy 2)
Krul, Debuchy (86' Tiote), Yanga-Mbiwa, Coloccini, Santon, Cabaye (62' Gouffran), Anita, Sissoko, Ben Arfa, Cisse (73' Marveaux), Remy
Subs: Williamson, Elliot, Sammy Ameobi, Dummett
ASTON VILLA 1 NEWCASTLE 2 (Ben Arfra, Gouffran)
Krul, Debuchy, Coloccini, Yanga-Mbiwa, Santon, Anita (74' Tiote), Cabaye (88' Sammy Ameobi), Ben Arfa, Sissoko, Remy (63' Gouffran), Cisse
Subs: Elliot, Marveaux, S Taylor, Dummett
NEWCASTLE 1 FULHAM 0 (Ben Arfa)
Krul, Debuchy, Yanga-Mbiwa, Coloccini, Santon, Ben Arfa, Sissoko, Anita 65' (Cabaye), Marveaux 74' (Remy), Shola Ameobi 65' (Gouffran), Cisse
Subs: Gosling, Elliot, Sammy Ameobi, Dummett
NEWCASTLE 0 WEST HAM 0
Krul, Debuchy, Yanga-Mbiwa, Coloccini, Santon, Ben Arfa, Sissoko, Anita, Marveaux 66' (Sammy Ameobi), Shola Ameobi, Cisse 72'
Subs: Gosling, Bigirimana, Elliot, Vuckic, Dummett
MAN CITY 4 NEWCASTLE 0
Krul, Debuchy, Coloccini, S Taylor, Yanga-Mbiwa, Sissoko, Tiote, Gouffran 45+4' (Dummett), Ben Arfa 65' (Sammy Ameobi), Gutierrez 44' (Anita), Cisse
Subs: Elliot, Marveaux, Shola Ameobi, Obertan
NEWCASTLE 2 LEEDS UTD 0 (Cisse, Gouffran)
Krul, Debuchy, Williamson, Coloccini, Dummett, Gouffran (90' Vuckic), Anita (80' Gosling), Tiote, Marveaux, Sammy Ameobi, Cisse (71' Obertan).
Subs: Ben Arfa, Yanga-Mbiwa, Bigirimana, Alnwick
MORECAMBE 0 NEWCASTLE 2 (Shola Ameobi, Sammy Ameobi)
Elliot, Debuchy, Yanga-Mbiwa, Good, Dummett, Bigirimana, Gosling, Marveaux 88' (Sissoko), Vuckic 46' (Shola Ameobi), Sammy Ameobi, Gouffran 71' (Ben Arfa)
Subs: Santon, Anita, Alnwick, Streete
Newcastle United Fixtures
Saturday October 19
12:45 Premier League
Newcastle United v Liverpool
Sunday October 27
13:30 Premier League
Sunderland v Newcastle United
Wednesday October 30
19:45 League Cup - 4th Rnd
Newcastle United v Manchester City
Saturday November 2
12:45 Premier League
Newcastle United v Chelsea
Sunday November 10
12:00 Premier League
Tottenham v Newcastle United