Mancini may be tempted to stick with the starting line-up from Monday's crucial win over Manchester United, although Micah Richards and James Milner might both hope to be involved.
City do have a good recent record on their visits to Tyneside, winning three times in an unbeaten four-match streak, and will be aiming for another success to take them a massive stride close to their first league title since 1968.
Newcastle midfielder Cheick Tiote will be fit despite suffering a nasty head injury in midweek.
The Ivory Coast international needed seven stitches to repair a gash above his eye after an aerial collision with John Obi Mikel in Wednesday night's 2-0 win at Chelsea, but manager Alan Pardew has no doubts he will be available for the City game.
Full-back Danny Simpson (ankle) remains a doubt, but only central defender Steven Taylor (Achilles) is still on the long-term injury list.
Newcastle (from): Krul, Elliot, Harper, Simpson, Santon, R. Taylor, Ferguson, Tavernier, Perch, Coloccini, Williamson, Tiote, Cabaye, Guthrie, Ben Arfa, Gutierrez, Obertan, Marveaux, Abeid, Gosling, Vuckic, Ba, Cisse, Shola Ameobi, Best.
Manchester City (from): Hart, Pantilimon, Richards, Zabaleta, Kompany, Lescott, Savic, K Toure, Kolarov, Clichy, Milner, Johnson, Nasri, De Jong, Barry, Y Toure, Pizarro, Silva, Balotelli, Aguero, Tevez, Dzeko.