Demba Ba, Moussa Sow, Issiar Dia, Kader Mangane and Souleymane Diawara have been ruled out.
The team which held a light training session on Friday evening at Namboole stadium.
Senegal rallied to beat Liberia last weekend while Uganda settled for a one-all draw with Angola in Luanda.
Coach Joseph Koto: “They cannot defend but will play attacking since Papiss Cisse, Souleymane Camara and Dame Ndoye will be in the team, despite missing the regulars.
Papiss Demba Cisse: “We are not under pressure since I can create goal assists for the team."