Alan Pardew confirmed Coloccini, 30, will be unavailable for the match after the Argentina international missed his country's recent fixtures against Peru and Paraguay because of a muscle injury.
Meanwhile Krul, 24, looks set to miss several games with an elbow injury, which was also picked on international duty, for Netherlands.
It is a bitter pill to swallow for Pardew who will go into the game missing four first-team players, with Cheick Tiote and Danny Simpson also confirmed as unavailable for the trip to Merseyside.
The enforced changes will likely see midfielder Vurnon Anita move to right-back, with Gael Bigirimana expected to earn a starting place after an impressive performance against Aston Villa last week.